Naringin improves post-ischemic myocardial injury by activation of KATP channels.

Naringin (NRG) is a flavonoid with recognized cardioprotective effects. Then, it was investigated the cardioprotective mechanisms of NRG against ischemia-reperfusion (I/R) injury. The rats were pretreated for 7 days (v.o.) with NRG (25 mg/kg) or n-acetylcysteine (NAC, 100 mg/kg) and their isolated hearts were subjected to global ischemia (30 min) and reperfusion (60 min). Furthermore, isolated hearts were perfused with 5 µM NRG in the presence of 10 µM glibenclamide (GLI) and subjected to I/R protocol. In healthy ventricular cardiomyocyte, it was evaluated the acute effect of 5 µM NRG on the GLI sensitive current. The results showed that NRG pretreatment restored the cardiac function and electrocardiogram (ECG) alterations induced by I/R injury, decreasing arrhythmia scores and the occurrence of severe arrhythmias. Lactate dehydrogenase and infarct area were decreased while superoxide dismutase (SOD), catalase and citrate synthase activities increased. Expression of SOD CuZn and SOD Mn not was altered. NRG treatment decreased reactive oxygen species (ROS) generation and lipid peroxidation without alter sulfhydryl groups and protein carbonylation. Also, NRG (5 µM) increased the glibenclamide sensitive current in isolated cardiomyocytes. In isolated heart, the cardioprotection of NRG was significantly reduced by GLI. Furthermore, NRG promoted downregulation of Bax expression and Bax/Bcl-2. Histopathological analysis showed that NRG decreased cell edema, cardiomyocytes and nucleus diameter. Thus, NRG has a cardioprotective effect against cardiac I/R injury which is mediated by its antioxidant and antiapoptotic actions and KATP channels activation.

Consumo alimentar em pacientes hospitalizados: associação com o estado nutricional e a anemia / Food consumption in hospitalized patients: association with nutritional status and anemia

Introdução: A anemia é um importante indicador de desnutrição e de ingestão alimentar inadequada podendo afetar pessoas de todas as faixas etárias. Objetivos: Analisar o consumo alimentar por meio do consumo de ferro (Fe), folato (B9 ou ácido fólico) e/ou cianocobalamina (B12), e a associação entre estado nutricional e anemia em pacientes hospitalizados. Métodos: A coleta foi realizada com pacientes institucionalizados adultos e idosos de ambos os sexos, visando averiguar determinantes de anemia nos mesmos, composta por dados clínicos, antropométricos e bioquímicos. Resultados: A amostra totalizou 123 pacientes, e revelou que mais de 80% dos estudados encontravam-se anêmicos. Não foi observada relação entre anemia e estado nutricional dos pacientes. Houve associação entre as vitaminas estudadas e a anemia. O índice de inadequação foi acentuado em todos os nutrientes referidos, destacando o folato (B9) com 93,19%. Conclusão: O resultado retrata que não houve relação do estado nutricional com a anemia, apesar dos índices elevados, porém foi encontrada associação da ingestão alimentar inadequada com a anemia (AU)

Introduction: Anemia is an important indicator of malnutrition and inadequate food intake can affect people of all age groups. Objective: Analyze food consumption through the iron intake (Fe), folate (B9 or folic acid) and / or cyanocobalamin (B12), and the association between nutritional status and anemia in hospitalized patients. Methods: Data collection was conducted with institutionalized adults and elderly patients of both sexes, aiming to investigate determinants of anemia on them, consisting of clinical, anthropometric and biochemical data. Results: The sample comprised 123 patients and found that more than 80% of the examined are anemic. No relationship was found between anemia and nutritional status of patients. There was a correlation between the studied vitamins and anemia. The inadequacy index was accentured in all nutrients mentioned, highlighting folate (B9) with 93.19%. Conclusion: The result depicts that there was no relationship between nutritional status and anemia, despite the high rates, but war correlated the inadequate food intake with anemia (AU)

Triagem, avaliação nutricional e presença de anemia em pacientes hospitalizados / Screening, nutrition assessment and anemia presence in patients hospitalized

Introdução: A ocorrência da desnutrição em pacientes hospitalizados é um problema de saúde pública. Porém, a desnutrição não é o único problema encontrado no ambiente hospitalar, onde a obesidade passou a ser considerada um problema de saúde pública, tão preocupante quanto a desnutrição. Objetivo: Avaliar o estado nutricional dos pacientes hospitalizados correlacionando a presença de anemia a métodos objetivos e subjetivos de avaliação nutricional. Métodos: Estudo transversal, realizado com pacientes adultos e idosos, em um hospital público de Aracaju-SE. Foram coletados dados antropométricos (métodos objetivos e subjetivos) e bioquímicos (hemoglobina). Resultados: Participaram da pesquisa 149 pacientes, dos quais 57% eram do gênero masculino com idade média de 48,88 ± 17,89. 124 pacientes (83,2%) eram anêmicos e a anemia correlacionou-se ao tempo de internação. Os métodos subjetivos foram mais precisos para diagnosticar desnutrição em adultos (ASG) e em idosos (MAN) em relação aos métodos objetivos. Conclusão: Quanto maior o tempo de internação maior o risco nutricional e maior probabilidade em desenvolver anemia. Espera-se que os achados do presente estudo possam contribuir para ampliar a assistência nutricional prestada aos pacientes hospitalizados a fim de evitar o aparecimento ou piora da desnutrição e anemia, reinternamentos e aumento dos custos hospitalares

Introduction: The incidence of malnutrition in hospitalized patients is a public health problem. But malnutrition is not the only problem encountered in the hospital setting, where obesity is now considered a public health problem, as worrying as malnutrition. Objective: To evaluate the nutritional status of hospitalized patients correlating the presence of anemia the objective and subjective methods of nutritional assessment. Methods: Cross-sectional study performed with adult and elderly patients in a public hospital in Aracaju-SE. We collected anthropometric data (objective and subjective methods) and biochemical (hemoglobin). Results: Participants were 149 patients, of whom 57% were male with an average age of 48.88 ± 17.89. 124 patients (83.2%) were anemic and anemia correlated to the length of stay. Subjective methods were more accurate for diagnosing malnutrition in adults (ASG) and the elderly (MAN) in relation to the objective methods. Conclusion: The longer the time of hospitalization greater nutritional risk and more likely to develop anemia. It is hoped that the findings of this study may contribute to enhance the nutritional care provided to hospitalized patients to prevent the onset or worsening of malnutrition and anemia, internments and increased hospital expense

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